You’ve developed an impressive ability to block out unwanted marketing messages in all their forms: popup ads, commercials, spam emails, etc.
Not only will this help improve your reputation with ISPs and prevent email bans, it will deliver more responses and increase engagement.
You can configure your subscription settings for any address to disable mail delivery via each mailing list's web interface.
Even postings made through the GMane news server need to be made from subscribed addresses because GMane simply forwards your postings on to the appropriate email list.
The first is to be strategic about the leads you acquire.
Lead scoring and grading solutions can automatically check each lead, assess their fit for your business, and assign to a list accordingly.
The second option is to allow your recipients to opt-in to receive emails.